RRS HA Long lasting Mesotherapy Solution

RRS HA Long Lasting is a sterile, resorbable mesotherapy dermal implant designed for professional use in aesthetic and dermatological practices. It combines cross-linked hyaluronic acid with a protective amino acid buffer to deliver deep, sustained hydration, improve skin elasticity, target superficial and moderate wrinkles, and revitalize photoaged or weakened skin. This product occupies a space between traditional skin boosters and fillers, offering both hydration and structural support without volumizing like standard fillers. 

It is classified as a Class III medical device under European regulations and should only be injected by qualified, trained medical professionals. 

Key Ingredients & Technology

Cross-Linked Hyaluronic Acid (HA)

• 21 mg / 3 mL of high-molecular-weight, biotechnologically produced HA that is cross-linked with BDDE to resist rapid degradation.

• Provides deep hydration and dermal support and improves skin turgor and smoothness.

• Slower biodegradation means results can be visible for up to ~9–12 months with appropriate clinical technique.

Amino Acid Buffer

• A proprietary blend (approx. 14.52 mg / 3 mL) of amino acids serves as a protective buffer.

• Helps stabilize the HA matrix, support gel integrity, and contribute mild antioxidant and osmotic balance benefits.

• The amino acid environment may also assist in reducing osmotic stress post-injection. 

Biotechnological, Non-Animal Origin

• HA is sourced via non-animal fermentation to improve tolerability and reduce allergenic risk. 

Mechanism of Action

When injected into the dermal (intradermal) layer of the skin, the product:

• Binds and retains water, increasing hydration and skin volume on a microstructural level.

• Supports fibroblast activity, which can enhance dermal matrix remodeling and collagen synthesis.

• Improves elasticity and skin density, so skin appears firmer and smoother.

• Plumps superficial lines and wrinkles through persistent moisture and structural reinforcement.

• Provides antioxidant support through the protective amino acid buffer.

• Results begin to be noticeable immediately and build over weeks, with longevity tied to metabolism, technique, and patient factors. 

Indications & Uses

RRS HA Long Lasting is intended for aesthetic procedures, including:

• Skin revitalization and biorevitalisation

• Treatment of photoaging and its signs

• Reduction of superficial and moderate wrinkles

• Improvement of dermal atrophy and thinning

• Enhanced hydration and skin firmness

• Antioxidant protection and prevention of further aging progression 

Common Treatment Areas:

• Face

• Neck

• Décolletage (as clinician protocol allows)

Application & Protocol

• Administration: Intradermal micro-injections by a trained medical professional.

• Needle Size: Typically 27–30G depending on technique and treatment area.

• Technique: Mesh-like micro-depot or micro-papular placement for even distribution.

• Treatment Frequency:

  • Standard protocols often include 1–3 treatments per year for best sustained results.

  • Some experts note that visible improvement can last up to 10–12 months with proper treatment planning. 

Benefits

Hydration & Plumping

• Deeply moisturizes the dermis and helps restore youthful skin volume without overt bulk.

Improved Skin Elasticity

• Increases dermal resilience and tensile strength.

Wrinkle Reduction

• Softens fine lines and moderate wrinkles through hydration and dermal matrix support. 

Skin Revitalization

• Enhances vitality, texture, and radiance of tired, photo-exposed skin. 

Antioxidant Protection

• The amino acid buffer helps guard against oxidative stress, aiding long-term skin health. 

Safety & Handling

• For professional use only in authorized aesthetic or dermatological clinics.

• Strict aseptic technique is required.

• Avoid use in areas of active infection or inflammation.

• Typical transient reactions may include mild swelling, redness, or slight bruising that resolves within days.

• Contraindications include pregnancy, breastfeeding, active dermatitis, uncontrolled autoimmune conditions, and known hypersensitivity to hyaluronic acid. 

Packaging & Storage

• Packaging: 1 pre-filled syringe of 3 mL

• Storage: Store at 2–25°C, protected from direct sunlight; do not freeze. 

Conclusion

RRS HA Long Lasting is a premium cross-linked hyaluronic acid-based mesotherapy implant uniquely formulated for long-lasting skin rejuvenation. It combines the hydration and structural enhancement of HA with supportive amino acids to deliver improved skin texture, elasticity, and wrinkle correction. The product is ideal for individuals seeking durable, natural-looking anti-aging results as part of a professional aesthetic treatment plan.